Unification Church founder Rev. Moon dies at 92

GAPYEONG, South Korea (AP) ? The Rev. Sun Myung Moon was a self-proclaimed messiah who built a global business empire. He called both North Korean leaders and American presidents his friends, but spent time in prisons in both countries. His followers around the world cherished him, while his detractors accused him of brainwashing recruits and extracting money from worshippers.

These contradictions did nothing to stop the founder of the Unification Church from turning his religious vision into a worldwide movement and a multibillion-dollar corporation stretching from the Korean Peninsula to the United States.

Moon died Monday at a church-owned hospital near his home in Gapyeong County, northeast of Seoul, two weeks after being hospitalized with pneumonia, Unification Church spokesman Ahn Ho-yeul told The Associated Press. Moon’s wife and children were at his side, Ahn said. He was 92.

The church will hold a 13-day mourning period beginning Monday and start accepting mourners Thursday at a multipurpose gym at its nearby religious center, the church said in a statement. The funeral will be held Sept. 15, and Moon will be buried at nearby Cheonseung Mountain, where his home is located, the statement said.

Moon founded his Bible-based religion in Seoul in 1954, a year after the Korean War ended, saying Jesus Christ personally called on him to complete his work.

The church gained fame ? and notoriety ? by marrying thousands of followers in mass ceremonies presided over by Moon himself. The couples often came from different countries and had never met, but were matched up by Moon in a bid to build a multicultural religious world.

Today, the Unification Church has 3 million followers, including 100,000 members in the U.S., and has sent missionaries to 194 countries, Ahn said. But ex-members and critics say the figure is actually no more than 100,000 members worldwide.

The church’s holdings included the Washington Times newspaper; Connecticut’s Bridgeport University; the New Yorker Hotel, a midtown Manhattan art deco landmark, and a seafood distribution firm that supplies sushi to Japanese restaurants across the U.S. It acquired a ski resort, a professional football team and other businesses in South Korea. It also operates a foreign-owned luxury hotel in North Korea and jointly operates a fledgling North Korean automaker.

The church has been accused of using devious recruitment tactics and duping followers out of money. Parents of followers in the United States and elsewhere have expressed worries that their children were brainwashed into joining. The church has pointed out that many new religious movements faced similar accusations in their early years. Moon’s followers were often called “Moonies,” a term many found pejorative.

Born in 1920 in a rural part of what is today North Korea, Moon said he was 16 when Jesus Christ first appeared to him and told him to finish the work he had begun on Earth 2,000 years earlier. Moon, who tried to preach the gospel in the North, was imprisoned there in the late 1940s for alleged spying for South Korea; he disputed the charge.

When the Korean War broke out in 1950, he went to South Korea. After divorcing his first wife, he married Hak Ja Han Moon in 1960. They have 10 surviving sons and daughters, according to the church.

In South Korea, Moon quickly drew young acolytes to his conservative, family-oriented value system and unusual interpretation of the Bible. He conducted his first mass wedding in Seoul in the early 1960s, and the “blessing ceremonies” grew in scale over the years. A 1982 wedding at New York’s Madison Square Garden ? the first outside South Korea ? drew thousands of participants.

“International and intercultural marriages are the quickest way to bring about an ideal world of peace,” Moon said in a 2009 autobiography. “People should marry across national and cultural boundaries with people from countries they consider to be their enemies so that the world of peace can come that much more quickly.”

Moon began building a relationship with North Korea in 1991, even meeting with the country’s founder, Kim Il Sung, in the eastern North Korean port city of Hamhung. In his autobiography, Moon said he urged Kim to give up his nuclear ambitions, and that Kim responded by saying that his atomic program was for peaceful purposes and he had no intention to use it to “kill my own people.”

“The two of us were able to communicate well about our shared hobbies of hunting and fishing,” Moon wrote. “At one point, we each felt we had so much to say to the other that we just started talking like old friends meeting after a long separation.”

When Kim died in 1994, Moon sent a condolence delegation to North Korea, drawing criticism from conservatives at home. The late Kim Jong Il, who succeeded his father as North Korean leader, sent roses, prized wild ginseng, Rolex watches and other gifts to Moon on his birthday each year. Moon said Kim Il Sung had instructed Kim Jong Il that “after I die, if there are things to discuss pertaining to North-South relations, you must always seek the advice of President Moon.”

The church also sent a delegation to pay its respects after Kim Jong Il died in December and was succeeded by his son Kim Jong Un.

Moon sought and eventually developed a good relationship with conservative American leaders such as former Presidents Richard Nixon, Ronald Reagan and George H.W. Bush.

Yet he also served 13 months at a U.S. federal prison in the mid-1980s after a New York City jury convicted him of filing false tax returns. The church says the U.S. government persecuted Moon because of his growing influence and popularity with young Americans.

In later years, the church adopted a lower profile in the United States and focused on building up its businesses. Moon lived for more than 30 years in the United States, the church said.

As he grew older, Moon also handed over day-to-day control of his empire to his children. His U.S.-born youngest son, the Rev. Hyung-jin Moon, was named the church’s top religious director in April 2008. Other children run the church’s businesses and charitable activities in South Korea and abroad.

In 2009, Moon married 45,000 people in simultaneous ceremonies worldwide in his first large-scale mass wedding in years, the church said. Some were newlyweds and others reaffirmed past vows. He married an additional 7,000 couples in South Korea in February 2010. The ceremonies attracted media coverage but little of the controversy that dogged the church in earlier decades.

Hyung-jin Moon told The Associated Press in February 2010 that his father’s offspring do not see themselves as his successors.

“Our role is not inheriting that messianic role,” he said. “Our role is more of the apostles … where we become the bridge between understanding what kind of lives (our) two parents have lived.”

___

AP writer Sam Kim contributed to this story from Seoul.

Source: http://news.yahoo.com/unification-church-founder-rev-moon-dies-92-185236876.html

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A Blood Red Summer

A Blood Red Summer

when their Volkswagen Vanagon breaks down in the middle of nowhere, miles from civilization the teens come face to face with a sadistic serial killer.

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“And I’m alone now,
Me and all I stood for.
We’re wandering now.
All in parts and pieces, swim lonely, find your own way out.”

(props if you know the lyrics without Google and if your as obsessed as me we just became best friends :D )

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This looks fab!! Would love to join, would I be able to change girl 2s face claim to candice accola?

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@Calvazara Yes mama i’ll change that for you right now!

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YAY! I am the Killer!

Austyn101 <—- One of the most awesome friends you’ll ever meet, and my very first love <3

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Video: Presidential campaigns diverting donations from food banks (cbsnews)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics – Top Stories News, News Feeds and News via Feedzilla.

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Education of Business Online from NCSU Ultimate Internet …

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Article by Aizza Wolton

How to make your business more findable online: NetMarketingFusion.com San Jose Internet Marketing Consultant Don Roberts (Certified Local Marketing Consultant) helps your business get more customers, more revenue, and more profits. Check-out the new Online Marketing ROI Calculator at netmarketingfusion.com
Video Rating: 5 / 5

This entry was posted in Internet Marketing Ideas and tagged Fiverivers, Internet, Marketing, Services, Ultimate. Bookmark the permalink. Follow any comments here with the RSS feed for this post. Trackbacks are closed, but you can .

Source: http://www.graspncsu.com/2012/09/ultimate-internet-marketing-services-fiverivers/

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Cogent strengthen pair of leader group, leader cad

The Supreme People, to listen to the inspection briefing attorney Cao Jianming demanded the full inspection system to strengthen the leadership ,www.louboutinoutletonsaleinusa.com,leader cadre to supervise the newspaper news ( reporter Xiao Wei ) recently ,the Supreme People held a party meeting ,listen to gaojianyuan went to Heilongjiang, Fujian ,Inner Mongolia 3 provinces ( area) patrol the report of the circumstance .
The Supreme People party secretary ,attorney Cao Jianming presided over the meeting and make important speech .Perambulatory group group leader ,He Subin ,Wang Ke Guo Yongyun representing three patrol group made special reports .
Cao Jianming first fully affirmed the three inspection teams to work ,he said ,according to the Party Central Committee about carrying out the inspection work requirements ,the end of year 3 to 4 at the end of the month ,gaojianyuan sent seventh batches perambulatory group of Heilongjiang ,Fujian ,Inner Mongolia 3 provinces ( area) the procuratorate were patrol .
Inspection group of comrades through in-depth and meticulous work ,not only fully affirmed by the patrol unit in team building ,work ,Louboutin Outlet,team building and achievement ,seek truth from facts and points out some problems that should be paid attention to ,especially found some common with ,typical of the deep-seated problems ,back to the basic level comrade on high school work very enlightening opinions and suggestions for the future of procuratorial organs ,strengthen leadership ,leader cadre team construction ,www.louboutinoutletshoesofusa.com,promoting the scientific development of procuratorial work has important significance .
The conference points out ,establish and improve the system of inspection tours ,it is the Party Central Committee in the new historical period for promoting the new great project of Party building ,to further strengthen the supervision within the party ,the discipline of earnest party ,improving the party and adopted major measures .
The procuratorial organ to carry out inspection work of procuratorial organs ,is the internal supervision system ,strengthening superior procuratorate to inferior procuratorates led an institutional innovation ,is to strengthen leading group construction ,promoting procuratorial organs party conduct Lianzheng construction is the important guarantee .
Practice has proved ,inspect the work of leadership ,leader cadre is a kind of supervision ,is one kind of restraint ,but is more of a concern ,care and protection .From the three inspection teams working circumstance looks ,the procuratorial organs execute patrol system effect is good .
We need to improve the ruling ability of the party ,consolidate the ruling status of the party the strategic height, from carry out to strengthen the legal supervision ,procuratorial work to safeguard fairness and justice theme needs, fully aware of the importance to carry out inspection work ,continue to hold to and perfect this system .
The conference emphasizes ,should highlight the inspection focus ,the procuratorial organs leading group ,leader cadre especially top leaders the focus of inspection .Procuratorial organs leading group especially attorney, in the procuratorial work in leader ,leader ,organizer ,supervisor position ,the procuratorial organs leading group especially the attorney general to exercise power correctly ,clean-fingered self-discipline ,concerning the procuratorial organs ,the image is related to the healthy development of the cause of .
Inspection work should focus on understanding the following several aspects :o ne is to carry out the party ,principles ,policies, especially the implementation of scientific outlook on development ,abide by the party discipline and conduct gaojianyuan major work deploy and resolution decision situation .
Two is the leader cadre clean-fingered self-discipline ,politics ,implementation of the responsibility system of .Especially to strengthen pair of leader cadres working circle ,life circle ,circle of supervision .
Three is to implement the Regulations on the work of selection and appointment of leading cadres ,employment situation .Four is the implementation of democratic centralism .Inspection should listen to masses of basic level cadre to gaojianyuan working opinions and suggestions ,especially for high house leadership ,www.louboutinpascherafr.com,leader cadre criticism .
Should dare and be good at discovering problems and deep-seated problems ,puts forward constructive opinion and proposal .Conference requirement ,the procuratorial organ should conscientiously implement the Regulations on inspection work of Communist Party of China (for Trial Implementation) ,further summarizing procuratorial organs inspection work experience ,perfect inspection system ,cogent play perambulatory job role ,strengthen inspection work in the actual results .
As of now ,gaojianyuan has sent 7 batches perambulatory group ,on 19 provincial procuratorate leading groups and their members were patrol .There are 30 provincial procuratorate were sent 286 inspection teams ,523 counties ( area) the procuratorate the leading group undertook patrol .
Through the inspection ,understand a lot of real situation ,as the Supreme People decision provides first hand material ;strengthen leadership ,leader cadre accept supervisory consciousness and consciousness, stimulative leader cadre clean-fingered self-discipline ;help patrol unit to solve some practical problems ,especially by procuratorate themselves cannot solve the cadre is adjusted ,funding and other issues; found some good work experience and outstanding leader cadre .
Practice has proved ,the inner-party supervision and inspection work of the lower ranking Procuratorate supervision organic union rises ,a better solution to the supervision ,supervision ,louboutin pas cher,to the lower supervision .
problem ,in strengthening the internal supervision plays an important role in .The conference thinks ,from the inspection situation, we should strengthen the work in the following four aspects :o ne is to take the leadership construction in the first place ,not only to solve the current problems ,and develop leadership construction in the medium and long term planning .
The two is to further correct handling guidelines handling duty-related criminal cases ,increase working strength ,give full play to the function of the procuratorial organ .Especially provincial Procuratorate ,both to increase under the guidance of strength, oneself also should lead to investigating the case .
Three is to fully understand the nature ,position and function of procuratorial committee ,christian louboutin shoes,further strengthening the procuratorial committee organization construction ,standard procedure ,cogent play procuratorial committee in procuratorial organs work and great and decision-making in the important role of .
The four is to attach great importance to team building ,strengthen the education ,christian louboutin outlet,management and supervision ,especially to strengthen pair of leader cadres , supervision ,the team of violations of law and discipline ,the investigation of serious investigation, which communicated with the timely notification ,absolutely not appeasement to protect .
Cao Jianming stressed ,should take seriously highly inspection found problems, targeted to take measures to solve the .Especially for the inspection found problems, to give chapter and verse for patrol unit to be feedback ,put forward the improvement suggestions .
The patrol unit will implement inspection proposed rectification ,write the report to the Supreme people .Gaojianyuan organs and units ,departments and the leadership to take the lead in implementing inspection advice ,relating to the local prosecutors to gaojianyuan organs of the criticisms and opinions ,Christian Louboutin Outlet,must study seriously, put forward the solution ,and resolutely rectification .
To further improve the style of work ,strengthen leadership ,to promote the scientific development of procuratorial work .Gaojianyuan deputy party secretary, deputy attorney general Zhang Geng ,deputy attorney general Hu Kehui ,Wang Zhenchuan ,Zhu Xiaoqing ,sun Qian ,louboutin,director of the Political Department of Zhang Changren ,the Central Commission for Discipline Inspection Group in high school Mo Wenxiu attended the meeting ,gaojianyuan procuratorial committee full-time member Wang Jianming to attend the conference .

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Biden: Obama leadership saved auto plants

LORDSTOWN, Ohio (AP) ? Vice President Joe Biden mounted the Democratic counterpoint to the Republican presidential ticket Friday, drawing attention to the Obama administration‘s rescue of the auto industry and portraying GOP presidential challenger Mitt Romney as a foe of government efforts to save jobs.

Laying out President Barack Obama’s indictment of Republican polices, Biden said that Rep. Paul Ryan, Romney’s running mate, has voted in Congress for measures that caused massive federal debts, including two wars, a prescription drug benefit and tax cuts for the wealthy that were not paid for.

“They call their plan new, bold and gutsy,” Biden told about 200 supporters in a union hall. “There is nothing gutsy about giving another trillion dollars in tax cuts to millionaires; there is nothing bold about turning Medicare into a voucher system. There is nothing bold about kicking 19 million kids and elderly off of Medicaid with no place else to go.”

Biden spoke about two miles from the sprawling GM plant in Lordstown in an event meant to emphasize the importance of the auto bailout to Ohio. The recoveries of GM and Chrysler have been recurrent themes in Obama’s re-election campaign, particularly in states such as Michigan and the battleground of Ohio.

Biden criticized Romney for opposing a taxpayer rescue of GM and Chrysler.

“What they didn’t acknowledge is Governor Romney‘s position was ‘let Detroit go bankrupt,’” he said, quoting the headline on a 2008 Romney opinion piece in the New York Times.

Ryan campaign spokesman Brendan Buck responded that Obama inherited a troubled economy but has made it worse.

“Like many towns across America, Janesville, Wis., is still waiting for the recovery the president promised,” Buck said, referring to Ryan’s hometown, where a GM auto plant was idled in 2008.

Biden’s remarks came as Romney and Ryan left their Republican National Convention in Tampa seeking the votes of former Obama supporters who have grown disenchanted with his presidency.

Obama traveled to Texas on Friday, where addressed military families on the second anniversary of the end of combat operations in Iraq.

___

Kuhnhenn reported from Washington.

Source: http://news.yahoo.com/biden-obama-leadership-saved-auto-plants-161852848.html

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Review of Our First International Business Class Experience ? Part 1 …

In early August, my husband and I did something that we had never before done ? we took our first international business class trip as we headed to the London Olympics. I know that is ?old hat? for some in the miles and points world, but for us it was a new and exciting experience. For once, we were not only looking forward to our trip, but we were also looking forward to the flight. It really is a shift in travel when the flight is a part of the vacation, as opposed to a means to an end. This is especially true since my husband had some anxiety about the length of the flight, flying over the ocean, etc. Before meeting me he had experienced some panic attacks on planes, so the only realistic way to get him to cross the ocean was to put him in a premium cabin where both his body and mind felt a bit more comfortable. If he wasn?t happy on this eight hour trip, then it would be very difficult to continue with the many ?larger? trips I have planned for the next couple years.? I needed him to have a great flying experience.? It worked.

Purchasing the Tickets:

We flew direct from Houston to London Heathrow on United. Only United and British Airways offer a direct from Houston to London, so our choices were limited pretty limited.? We avoid connections whenever possible to limit the likelihood of delays, and to ensure we are away from home as little time as possible, so any flight with a connection was a no-go for this relatively short trip. In the end, we decided to fly United over British Airways mainly because it would really help both of us achieve elite status. As a result of the miles earned from the flight, my husband just obtained Silver status, and I am on track to hit Platinum with United by the end of the year.? Elite status will help make travel more comfortable and flexible for our family, so it is an important factor when we decide which tickets to purchase.

We managed to get a solid deal on purchasing the BusinessFirst tickets as a result of a sale tied to the Olympics and the year 2012.? Normally we would use miles for a premium cabin trip like this, but purchasing this ticked was doable for us because my husband?s job picked up the tab for his ticket since he had work to do in the UK. In essence, we had a BOGO deal on an already discounted business class ticket. We each earned about 15,000 redeemable and elite qualifying miles from the trip.

The handy dandy MileValue calculator tells me that when you take into account the 15,000 miles we earned on the ticket, we would have been getting a 1.74 cent per mile return on our miles had we used them instead of cash. That isn?t a terrible redemption value, but it is below the two cents per mile that I try to shoot for with United miles. Long story short, using cash made sense in this case since we only needed one ticket, and the redemption value wasn?t worth it to use miles this time. Now if we needed three tickets for our whole family, the equation would have very much shifted!

Boarding and Pre-Departure:

We were booked on a 777-200, and it looked impressive even as we saw it from the windows at the gate.? It?s not the largest aircraft in the United fleet, but since most of my United flights are on much smaller 737s, this was a definite step-up!? I would be remiss to not point out how excited we were when we got to board first and then follow the signs to the BusinessFirst cabin. I think the guy behind us rolled his eyes when I took a picture of the sign, but we were too excited to care. This was special for us and we wanted to soak in every minute.? Yes, we are total nerds.?

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Once we boarded, a flight attendant almost immediately came over to welcome us and take my jacket. We were offered a pre-departure beverage, and I very happily ordered a glass of red wine. I was feeling very sad about leaving my kid behind, and needed something to take the edge of.? If you haven?t yet had this experience, it felt very different leaving her to go to another continent than it does to fly to another state for a few days.? I didn?t cry, but I probably came pretty close as my mom was texting me videos of C while the plane boarded. For the record, they were watching the Lufthansa A380 take off from IAH while we were waiting for our flight.? It had just started flying out of Houston that week ? my whole family is full of airline junkies at heart.

20120830-142021.jpg

We were also personally informed of what weather would be en route to London that night, and when it was likely that we might expect some turbulence. They say the same thing to everyone in business class, but it was still a nice touch. Certainly isn?t something you would be told in coach.? ;) ? There is a pillow, blanket, headphones, and amenity kit waiting on each chair. I?m pretty simple, so the fact that they give you toothpaste was pretty exciting to me. It is also quite handy to have readily available ? they really should do some form of that for all cabins on an overnight international flight.

20120830-142034.jpg

Before everyone had finished boarding (and before he had even finished one drink) my husband was all smiles.? He isn?t one of those people that naturally looks happy and smiley all the time, so this was genuine.? Is a premium cabin worth it on some special trips?? To me this picture is worth 1,000 words, and the plane had yet to leave the ground.

20120830-142116.jpg

In Part 2 of the post that will be available tomorrow, I will cover the inflight entertainment, the meals, the lie-flat seat, and some thoughts on children in the BusinessFirst Cabin.? We didn?t have our child with us on this flight, but I was very much thinking about logistics of traveling with her on a future international adventure.

Source: http://boardingarea.com/blogs/mommypoints/2012/08/31/review-of-our-first-international-business-class-experience-part-1/

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MGM RESORTS INTERNATIONAL : Names President & COO of Casino Marketing

08/31/2012 | 08:50am US/Eastern

LAS VEGAS, Aug. 31, 2012 /PRNewswire/ — MGM Resorts International (NYSE: MGM) has named an industry leader to the newly created position of company President & COO of Casino Marketing.

Anton Nikodemus was named to the position by Bill Hornbuckle, MGM Resorts Chief Marketing Officer.

“Anton will be responsible for strategic planning for Casino Marketing including marketing development, both nationally and internationally,” Hornbuckle said. “The creation of the new position is rooted in the MGM Resorts strategic plan’s focus on growth,” Hornbuckle added.

Nikodemus will provide leadership in the strategic planning process for casino marketing, special events, customer development teams and programs, governance, and credit/collection decisions. He will lead strategic planning efforts for future marketing development. He will also coordinate efforts between senior management and be responsible for developing, implementing and managing all aspects of National Casino Marketing, National Branch Offices, International Marketing and International Branch Offices.

Nikodemus joined MGM Resorts International in 2005 as Senior Vice President of Hotel Operations for MGM Grand Las Vegas. Most recently, Nikodemus was President and Chief Operating Officer for Monte Carlo Resort and Casino where he repositioned the property’s performance by developing and deploying highly successful strategies in the domestic and international markets.

Prior to joining MGM Resorts, Nikodemus served as Resort Manager for Boca Raton Resort and Club in Boca Raton, Florida where he oversaw numerous multimillion dollar renovations and a strong Five-Diamond service culture. He also served as President for the Palm Beach County Convention and Visitors Bureau. He is a graduate of Arizona State University with a Bachelor of Science degree in Business Management and Marketing.

About MGM Resorts International
MGM Resorts International (NYSE: MGM) is one of the world’s leading global hospitality companies, operating a peerless portfolio of destination resort brands, including Bellagio, MGM Grand, Mandalay Bay and The Mirage. For more information about MGM Resorts International, visit the Company’s website at www.mgmresorts.com.

SOURCE MGM Resorts International

Source: http://www.4-traders.com/MGM-RESORTS-INTERNATIONAL-13513/news/MGM-RESORTS-INTERNATIONAL-Names-President-COO-of-Casino-Marketing-14483214/

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New genetic risk factor for inflammation identified in African-American women

[ Back to EurekAlert! ] Public release date: 30-Aug-2012
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center

Inflammatory marker is linked with increased risk of heart disease, diabetes and some cancers

SEATTLE African Americans have higher blood levels of a protein associated with increased heart-disease risk than European Americans, despite higher “good” HDL cholesterol and lower “bad” triglyceride levels. This contradictory observation now may be explained, in part, by a genetic variant identified in the first large-scale, genome-wide association study of this protein involving 12,000 African American and Hispanic American women.

Lead researcher Alexander Reiner, M.D., an epidemiologist at Fred Hutchinson Cancer Research Center, and colleagues describe their findings online ahead of the Sept. 7 print issue of the American Journal of Human Genetics.

Specifically, the researchers looked for genetic signposts associated with elevated levels of C-reactive protein, or CRP a marker of inflammation that is linked with increased risk of heart disease, diabetes and some cancers.

“Most previous studies examining the genetic determinants of elevated CRP have focused on tens of thousands of white individuals of European descent,” said Reiner, a member of the Hutchinson Center’s Public Health Sciences Division. “Since minorities African Americans and Hispanic Americans in particular tend to have higher CRP levels than other U.S. racial and ethnic groups, it’s important to understand whether genetic factors might contribute to these differences.”

Reiner and colleagues identified several genetic factors linked to CRP that are relatively specific to African Americans. They found a variation in TREM2, a family of genes on chromosome 6p21 that are expressed in white blood cells and appear to be important for regulating the degree of inflammation generated when white blood cells respond to infection or tissue injury.

“TREM genes were recognized relatively recently to be involved in inflammation and autoimmune disorders. Our finding adds further support to the importance of this gene family in generating and regulating inflammatory responses,” said Reiner, who is also a professor of epidemiology at the University of Washington School of Public Health.

They also discovered that approximately 20 previously identified genetic factors associated with elevated CRP in whites are also shared among African Americans and Hispanic Americans genes that involve pathways related to innate immunity as well as metabolism of fat and sugar.

Identifying the genetic variants that regulate CRP levels may help researchers settle a point of scientific controversy: whether chronic, low-grade inflammation causes cardiovascular disease or whether it is just a reaction to the disease process of atherosclerosis, also known as hardening of the arteries.

“This finding may allow us to study whether CRP is a direct cause of heart disease or merely an early warning sign,” Reiner said. “Moreover, understanding the genes that regulate the inflammatory response in humans could lead to the development of new anti-inflammatory drugs for treatment of an assortment of chronic diseases ranging from diabetes to cancer.”

In addition to genetics, environmental factors that are known to contribute to elevated CRP and low-grade, chronic inflammation include obesity, cigarette smoking and estrogen therapy.

While low-grade inflammation may contribute to increased risk of cardiovascular disease and other health disparities among African Americans and Hispanic Americans, prior studies suggest the correlation between CRP and obesity does not appear to completely explain higher CRP levels among people of African descent.

For the study, Reiner and colleagues scanned the genomes of 8,280 African American and 3,548 Hispanic American, postmenopausal participants in the Women’s Health Initiative to look for variations in DNA called single-nucleotide polymorphisms, or SNPs that were associated with elevated CRP. The Hutchinson Center houses the Clinical Coordinating Center of the WHI, one of the largest U.S. prevention studies of its kind involving more than 161,000 women nationwide.

“This pool of genotyping data offers unique and exciting opportunities to search for genetic factors that influence disease risks in the two largest minority populations in the United States: African Americans and Hispanics,” said senior author Hua Tang, Ph.D., an associate professor of genetics and statistics at Stanford University. These groups suffer disproportionate burdens of heart disease, certain types of cancer and other illnesses but are under-represented in many ongoing genetic-association studies. “Our ultimate goal is to design better disease prevention, diagnostic and therapeutic strategies so that all people can benefit from advancements in genomics medicine,” Tang said.

###

The National Heart, Lung and Blood Institute, the National Institutes of Health and the U.S. Department of Health and Human Services funded the research, which also involved collaborators at the University of North Carolina at Chapel Hill and the University of Iowa.

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit www.fhcrc.org.



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[ Back to EurekAlert! ] Public release date: 30-Aug-2012
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center

Inflammatory marker is linked with increased risk of heart disease, diabetes and some cancers

SEATTLE African Americans have higher blood levels of a protein associated with increased heart-disease risk than European Americans, despite higher “good” HDL cholesterol and lower “bad” triglyceride levels. This contradictory observation now may be explained, in part, by a genetic variant identified in the first large-scale, genome-wide association study of this protein involving 12,000 African American and Hispanic American women.

Lead researcher Alexander Reiner, M.D., an epidemiologist at Fred Hutchinson Cancer Research Center, and colleagues describe their findings online ahead of the Sept. 7 print issue of the American Journal of Human Genetics.

Specifically, the researchers looked for genetic signposts associated with elevated levels of C-reactive protein, or CRP a marker of inflammation that is linked with increased risk of heart disease, diabetes and some cancers.

“Most previous studies examining the genetic determinants of elevated CRP have focused on tens of thousands of white individuals of European descent,” said Reiner, a member of the Hutchinson Center’s Public Health Sciences Division. “Since minorities African Americans and Hispanic Americans in particular tend to have higher CRP levels than other U.S. racial and ethnic groups, it’s important to understand whether genetic factors might contribute to these differences.”

Reiner and colleagues identified several genetic factors linked to CRP that are relatively specific to African Americans. They found a variation in TREM2, a family of genes on chromosome 6p21 that are expressed in white blood cells and appear to be important for regulating the degree of inflammation generated when white blood cells respond to infection or tissue injury.

“TREM genes were recognized relatively recently to be involved in inflammation and autoimmune disorders. Our finding adds further support to the importance of this gene family in generating and regulating inflammatory responses,” said Reiner, who is also a professor of epidemiology at the University of Washington School of Public Health.

They also discovered that approximately 20 previously identified genetic factors associated with elevated CRP in whites are also shared among African Americans and Hispanic Americans genes that involve pathways related to innate immunity as well as metabolism of fat and sugar.

Identifying the genetic variants that regulate CRP levels may help researchers settle a point of scientific controversy: whether chronic, low-grade inflammation causes cardiovascular disease or whether it is just a reaction to the disease process of atherosclerosis, also known as hardening of the arteries.

“This finding may allow us to study whether CRP is a direct cause of heart disease or merely an early warning sign,” Reiner said. “Moreover, understanding the genes that regulate the inflammatory response in humans could lead to the development of new anti-inflammatory drugs for treatment of an assortment of chronic diseases ranging from diabetes to cancer.”

In addition to genetics, environmental factors that are known to contribute to elevated CRP and low-grade, chronic inflammation include obesity, cigarette smoking and estrogen therapy.

While low-grade inflammation may contribute to increased risk of cardiovascular disease and other health disparities among African Americans and Hispanic Americans, prior studies suggest the correlation between CRP and obesity does not appear to completely explain higher CRP levels among people of African descent.

For the study, Reiner and colleagues scanned the genomes of 8,280 African American and 3,548 Hispanic American, postmenopausal participants in the Women’s Health Initiative to look for variations in DNA called single-nucleotide polymorphisms, or SNPs that were associated with elevated CRP. The Hutchinson Center houses the Clinical Coordinating Center of the WHI, one of the largest U.S. prevention studies of its kind involving more than 161,000 women nationwide.

“This pool of genotyping data offers unique and exciting opportunities to search for genetic factors that influence disease risks in the two largest minority populations in the United States: African Americans and Hispanics,” said senior author Hua Tang, Ph.D., an associate professor of genetics and statistics at Stanford University. These groups suffer disproportionate burdens of heart disease, certain types of cancer and other illnesses but are under-represented in many ongoing genetic-association studies. “Our ultimate goal is to design better disease prevention, diagnostic and therapeutic strategies so that all people can benefit from advancements in genomics medicine,” Tang said.

###

The National Heart, Lung and Blood Institute, the National Institutes of Health and the U.S. Department of Health and Human Services funded the research, which also involved collaborators at the University of North Carolina at Chapel Hill and the University of Iowa.

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit www.fhcrc.org.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/fhcr-ngr082712.php

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